Detalhe da pesquisa
1.
Development and optimization of a high-throughput screening assay for in vitro anti-SARS-CoV-2 activity: Evaluation of 5676 Phase 1 Passed Structures.
J Med Virol;
94(7): 3101-3111, 2022 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35229317
2.
In vitro activity of itraconazole against SARS-CoV-2.
J Med Virol;
93(7): 4454-4460, 2021 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33666253
3.
A new modeling approach for quantifying expert opinion in the drug discovery process.
Stat Med;
34(9): 1590-604, 2015 Apr 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25705858
4.
Impact of selection bias on the evaluation of clusters of chemical compounds in the drug discovery process.
Pharm Stat;
14(2): 129-38, 2015.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25420717
5.
A flexible, image-based, high-throughput platform encompassing in-depth cell profiling to identify broad-spectrum coronavirus antivirals with limited off-target effects.
Antiviral Res;
222: 105789, 2024 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38158129
6.
Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2.
Microorganisms;
11(3)2023 Mar 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36985290
7.
Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor.
Commun Biol;
5(1): 787, 2022 08 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35931745
8.
Library enhancement through the wisdom of crowds.
J Chem Inf Model;
51(12): 3275-86, 2011 Dec 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22035213
9.
Identification of novel inhibitors of rat Mrp3.
Eur J Pharm Sci;
162: 105813, 2021 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33753214
10.
Monte Carlo simulations using PELE to identify a protein-protein inhibitor binding site and pose.
RSC Adv;
10(12): 7058-7064, 2020 Feb 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35493910
11.
Lack of antiviral activity of darunavir against SARS-CoV-2.
Int J Infect Dis;
97: 7-10, 2020 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32479865
12.
Design, Synthesis, and Biological Evaluation of Novel Indoles Targeting the Influenza PB2 Cap Binding Region.
J Med Chem;
62(21): 9680-9690, 2019 11 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31647875
13.
A small-molecule fusion inhibitor of influenza virus is orally active in mice.
Science;
363(6431)2019 03 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30846569
14.
Electrophile-induced bromocyclization of gamma,delta-unsaturated ketimines to intermediate 1-pyrrolinium salts and their selective conversion into novel 5-alkoxymethyl-2-aryl-3-chloropyrroles and 2-aroylpyrroles.
Org Biomol Chem;
6(20): 3667-9, 2008 Oct 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18843395
15.
Protocols for the Design of Kinase-focused Compound Libraries.
Mol Inform;
37(5): e1700119, 2018 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29116686
16.
Potent peptidic fusion inhibitors of influenza virus.
Science;
358(6362): 496-502, 2017 10 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28971971
17.
Extending kinome coverage by analysis of kinase inhibitor broad profiling data.
Drug Discov Today;
20(6): 652-8, 2015 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25596550
18.
2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase.
J Med Chem;
53(22): 8150-60, 2010 Nov 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21033671